Orthopedic surgery research focuses on the diagnosis, treatment and prevention of conditions affecting the bones, joints, muscles, ligaments and tendons. Our orthopedic clinical trials may involve new surgical techniques, devices, implants, medications, or rehabilitation approaches designed to improve mobility and musculoskeletal health.

Organs Include:
• Bones
• Joints
• Muscles
• Tendons
• Ligaments

Common Conditions:
• Osteoarthritis
• Joint injuries (knee, hip, shoulder)
• Fractures and broken bones
• Rotator cuff tears
• Spine disorders
• Carpal tunnel syndrome
• Tendon or ligament injuries (e.g., ACL tears)
• Chronic musculoskeletal pain
• Sports injuries

To learn more about participating in a clinical trial, please contact us at 

1-800-836-0388 or clinical.research@guthrie.org

Title: * Flatiron Health Parent Protocol for Prospective Real World Studies (PrwS Parent Protocol - FH-PrwS-07)

** Molecular Residual Disease in Solid Tumors: A Prospective Study to Collect Clinical Data and Biospecimens to Support Discovery and Development of Cancer Biomarkers (Substudy Number: FH-PrwS-07-002)
Department: Oncology
Diagnosis: Cancer - Oncology
Principal Investigator:

Macfie MD, Rebekah

Sponsors: Flatiron Health, Inc.
Details (Identifier #): NCT06605404
Title: A Phase 2, Open-Label, Randomized, Global Study of Two Telisotuzumab Vedotin Regimens in Subjects with Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer
Department: Oncology
Diagnosis: Cancer - Lung
Principal Investigator:

Poulose MD, Joyson

Sponsors: AbbVie
Details (Identifier #): NCT06568939
Title: A Phase 3 Randomized, Double-Blind, Active-Controlled
Study of Palazestrant with Ribociclib Versus Letrozole with
Ribociclib for the First-Line Treatment of ER+, HER2
Advanced Breast Cancer (OPERA-02)
Department: Oncology
Diagnosis: Cancer - Breast
Principal Investigator:

Poulose MD, Joyson

Sponsors: Olema Pharmaceuticals, Inc.
Details (Identifier #): NCT07085767
Title: A Phase 3 Randomized, Open-Label Study of OP-1250 Monotherapy vs Standard of Care for the Treatment of ER+, HER2- Advanced or Metastatic Breast Cancer Following Endocrine and CDK 4/6 Inhibitor Therapy (OPERA-01)
Department: Oncology
Diagnosis: Cancer - Breast
Principal Investigator:

Poulose MD, Joyson

Sponsors: Olema Pharmaceuticals, Inc.
Details (Identifier #): NCT06016738
Title: A Prospective, Multi-Center, Non-Randomized, SinGle-Arm Study of the BDTM Low ProfILe Vascular Covered Stent in PerIpheral ArTerY Disease (AGILITY)
Department: Vascular Surgery
Diagnosis: Vascular Disease
Principal Investigator:

Marica M.D., Silviu

Sponsors: Becton, Dickinson and Company
Details (Identifier #): NCT06111469
Title: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 STUDY OF VE303 FOR PREVENTION OF RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION:
THE RESTORATIVE303 STUDY
Department: Gastroenterology
Diagnosis: Gastrointestinal - Miscellaneous
Principal Investigator:

Srivatana MD, Ukorn

Sponsors: Vedanta Biosciences, Inc.
Details (Identifier #): NCT06237452
Title: A Randomized, Double-blinded, Multicenter, Phase III Clinical Study of HLX22 (Recombinant Humanized Anti-HER2 Monoclonal Antibody Injection) in Combination with Trastuzumab and Chemotherapy (XELOX) versus Trastuzumab and Chemotherapy (XELOX) with or without Pembrolizumab for the First Line Treatment of Locally Advanced or Metastatic Gastroesophageal Junction and Gastric Cancer
Department: Oncology
Diagnosis: Cancer - Oncology
Principal Investigator:

Poulose MD, Joyson

Sponsors: Shanghai Henlius Biotech, Inc.
Details (Identifier #): NCT06532006
Title: A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients with End-Stage Renal Disease
Department: Vascular Surgery
Diagnosis: Vascular Disease
Principal Investigator:

Hussain DO, Amber

Sponsors: W. L. Gore & Associates, Inc.
Title: A032102, PREcision DIagnostics in prostate Cancer Treatment (PREDICT)
Department: Oncology
Diagnosis: Cancer - Oncology
Sponsors: ALLIANCE
Details (Identifier #): NCT06632977
Title: ALLIANCE A222004:
A RANDOMIZED PHASE III TRIAL OF OLANZAPINE VERSUS MEGESTROL ACETATE FOR CANCER-ASSOCIATED ANOREXIA
Department: Oncology
Diagnosis: Cancer - Oncology
Principal Investigator:

Poulose MD, Joyson

Sponsors: ALLIANCE
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