Clinical Trials

If you would like to explore the possibility of participating in a clinical trial at Guthrie, please call 1-800-836-0388.
Title: A Phase 2, Dose-finding, Randomized,
Double-blind, Placebo-controlled, Multicenter
Study to Evaluate the Safety and Efficacy of
Efavaleukin Alfa Induction Therapy in Subjects
with Moderately to Severely Active Ulcerative
Colitis
Department: Gastroenterology
Diagnosis: Gastrointestinal - Ulcerative Colitis
Principal Investigator: Matthew Lincoln, DO
Sponsors: Amgen
Details (Indentifier #): 04987307
Title: A011801: The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinib
Department: Oncology
Diagnosis: Breast- Adjuvant
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04457596
Title: A021502: Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair
Department: Oncology
Diagnosis: Gastrointestinal - Colon-Rectal
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT02912559
Title: A021703: Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients With Previously Untreated Metastatic Colorectal Cancer (SOLARIS)
Department: Oncology
Diagnosis: Gastrointestinal - Colon-Rectal
Principal Investigator: Philip A Lowry, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04094688
Title: A031704: PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer [PDIGREE]
Department: Oncology
Diagnosis: Genito-urinary - Renal
Principal Investigator: Philip A Lowry, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT03793166
Title: A031902 CASPAR - A Phase III Trial of Enzalutamide and Rucaparib as a Novel Therapy in First-Line Metastatic Castration-Resistant Prostate Cancer
Department: Oncology
Diagnosis: Genito-urinary - Prostate
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04455750
Title: A071801: Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease
Department: Oncology
Diagnosis: Brain
Principal Investigator: Thomas J Gergel, MD
Sub-Investigator(s):
Sponsors: ALLIANCE
Details (Indentifier #): NCT04114981
Title: A171901: OLDER NON-SMALL CELL LUNG CANCER PATIENTS (>/= 70 YEARS OF AGE) TREATED WITH FIRST-LINE MK-3475 (PEMBROLIZUMAB) +/- CHEMOTHERAPY (ONCOLOGIST'S/PATIENT'S CHOICE)
Department: Oncology
Diagnosis: Lung- Non-Small Cell
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04533451
Title: Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)
Department: Oncology
Diagnosis: Lung- Miscellaneous
Principal Investigator: Philip A Lowry, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT02194738
Title: AFT-25 COMET Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial For Low Risk DCIS
Department: Oncology
Diagnosis: Breast
Principal Investigator: M. Firdos Ziauddin, MD, FACS
Sponsors: AFT
Details (Indentifier #): NCT02926911
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