If you would like to explore the possibility of participating in a clinical trial at Guthrie, please call 1-800-836-0388.

As a Guthrie cancer patient you will have the unique opportunity to participate in one or more of some 100 clinical research trials that involve new treatments for many cancer types.

As a Guthrie patient you may have the unique opportunity to take part in clinical research trials for atrial fibrillation, congestive heart failure, lipid disorders, heart attack and many more cardiology disease states.

As a Guthrie patient you may have an opportunity to take part in clinical research trials for celiac disease, Crohn’s disease, ulcerative colitis, reflux disease, hepatitis and many more gastroenterology disease states.

Clinical trials study new ways to prevent, detect and treat disease. If you take part in research, you help advance new investigational medical therapies. 

Title: A011801: The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinib
Department: Oncology
Diagnosis: Breast- Adjuvant
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04457596
Title: A021502: Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair
Department: Oncology
Diagnosis: Gastrointestinal - Colon-Rectal
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT02912559
Title: A021703: Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients With Previously Untreated Metastatic Colorectal Cancer (SOLARIS)
Department: Oncology
Diagnosis: Gastrointestinal - Colon-Rectal
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04094688
Title: A031704: PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer [PDIGREE]
Department: Oncology
Diagnosis: Genito-urinary - Renal
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT03793166
Title: A031902 CASPAR - A Phase III Trial of Enzalutamide and Rucaparib as a Novel Therapy in First-Line Metastatic Castration-Resistant Prostate Cancer
Department: Oncology
Diagnosis: Genito-urinary - Prostate
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04455750
Title: A171901: OLDER NON-SMALL CELL LUNG CANCER PATIENTS (>/= 70 YEARS OF AGE) TREATED WITH FIRST-LINE MK-3475 (PEMBROLIZUMAB) +/- CHEMOTHERAPY (ONCOLOGIST'S/PATIENT'S CHOICE)
Department: Oncology
Diagnosis: Lung- Non-Small Cell
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT04533451
Title: Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)
Department: Oncology
Diagnosis: Lung- Miscellaneous
Principal Investigator: Joyson Poulose, MD
Sponsors: ALLIANCE
Details (Indentifier #): NCT02194738
Title: AFT-25 COMET Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial For Low Risk DCIS
Department: Oncology
Diagnosis: Breast
Principal Investigator: M. Firdos Ziauddin, MD, FACS
Sponsors: AFT
Details (Indentifier #): NCT02926911
Title: BNT111-01: Open-label, Randomized Phase II Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD1-refractory/Relapsed, Unresectable Stage III or IV Melanoma
Department: Oncology
Diagnosis: Melanoma
Principal Investigator: Joyson Poulose, MD
Sponsors: BioNTech
Details (Indentifier #): NCT04526899
Title: EA5181: Randomized Phase III Trial of MEDI4736 (Durvalumab) as Concurrent and Consolidative Therapy or Consolidative Therapy Alone for Unresectable Stage 3 NSCLC
Department: Oncology
Diagnosis: Lung- Non-Small Cell
Principal Investigator: Joyson Poulose, MD
Sponsors: ECOG-ACRIN
Details (Indentifier #): NCT04092283
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