As you jump on the GLP-1 bandwagon, you may need to take a few extra precautions.

GLP-1 medications have changed the way doctors treat obesity and type 2 diabetes. And now that Medicare is covering medications like Ozempic, Wegovy, Mounjaro and Zepbound for more people, many older adults who couldn't afford them before are starting treatment.

These medications can help people lose weight, improve blood sugar and lower the risk of some obesity-related health problems. But it's important to remember that as you get older, protecting your muscles and bones and prioritizing your overall nutrition becomes just as important as maintaining a healthy weight.

Here are a few things older adults should consider when taking GLP-1 medications.

Be Proactive About Muscle Loss

Everyone loses some muscle with age, but GLP-1 medications can make it worse if you're not eating enough protein or staying active. Losing muscle makes everyday activities like climbing stairs, carrying groceries or getting out of a chair more difficult. It also increases your risk of falls.

Because these medications reduce your appetite, you may eat much less. While that helps with weight loss, it may also mean you're not getting enough nutrients to maintain your muscles.

One of the best ways to protect muscles is to eat protein at every meal (here are some delicious high protein GLP-1 recipes to try) and to enjoy protein-rich snacks. It's also important to do strength training exercises a few times each week. Resistance bands, light dumbbells or body weight exercises are all good choices.

Don't Forget Bone Health

Rapid weight loss may also affect bone health. This is especially important for older adults, who already have a higher risk of osteoporosis and fractures.

Getting enough calcium and vitamin D supports healthy bones. Dairy foods, fortified plant milks, yogurt and canned salmon with bones are good choices. Your healthcare provider may also recommend supplements if needed. Weight-bearing and strength exercises also help keep bones stronger.

Watch for Dehydration

Older adults are already more likely to become dehydrated because their sense of thirst becomes weaker with age. GLP-1 medications can add to that risk, especially if nausea, vomiting or diarrhea occur.

Pay attention to signs of dehydration such as dark urine, dizziness, dry mouth, headaches and feeling unusually tired. To combat dehydration, sip water throughout the day instead of waiting until you feel thirsty. Broth-based soups, fruit and vegetables with a high water content also help you stay hydrated.

Monitor Your Medications

GLP-1s may affect other medications you take. Since the drugs slow the digestive process, it may take longer for medications to kick in. Consuming less of some nutrients may also throw off how some medications work. And as you lose weight, you may need to adjust your medications so it's best to have a doctor monitor this closely.

Stay In Touch with Your Healthcare Team

GLP-1 medications can be very effective for older adults, but they work best when combined with good nutrition, regular exercise and ongoing medical care. Talk to your healthcare provider if you're losing weight very quickly, feeling weak, becoming dehydrated or having trouble eating enough.

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Date Last Reviewed: July 17, 2026

Editorial Review: Andrea Cohen, Editorial Director, Baldwin Publishing, Inc. Contact Editor

Medical Review: Jane Schwartz, RDN, CLT

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