Although sold over the counter, some supplements may cause more harm than good.

You probably already know that what you eat can affect your blood pressure. But what about the vitamins, minerals and herbal supplements in your medicine cabinet?

Many people take supplements to boost their energy, support their immune system or improve their overall health, and because they're sold over the counter, it's easy to assume they're harmless. However, some supplements can interact with medications, while others can make health conditions harder to manage.

If you have high blood pressure, you should be especially careful about the supplements you take. Some can raise blood pressure, affect heart rate or interfere with blood pressure medications. Knowing which products to avoid can help you better manage your blood pressure and keep your heart healthier.

Here are some supplements to use with caution if you have high blood pressure.

Licorice Root

Licorice root is one of the biggest concerns for people with high blood pressure. It contains a compound called glycyrrhizin, which can cause the body to retain sodium and lose potassium. This combination can lead to higher blood pressure and may increase the risk of heart problems.

Many people take licorice root supplements for digestive issues or other health concerns without realizing they can affect blood pressure. Some herbal teas and natural products also contain licorice root.

Ginseng

Ginseng is often marketed as an energy booster or immune support supplement. However, research suggests it may affect blood pressure in different ways, sometimes causing it to rise.

Because its effects can be unpredictable, experts often recommend that people with high blood pressure avoid ginseng supplements unless their healthcare provider specifically approves them.

Bitter Orange

Bitter orange is commonly found in weight loss and sports performance supplements. It contains compounds that can stimulate the body in ways that raise blood pressure and heart rate.

Some manufacturers began using bitter orange after ephedra was removed from products due to safety concerns. But even though it's sold as a natural supplement, it may still pose risks for people with hypertension.

Yohimbe

Yohimbe is sometimes promoted for weight loss, athletic performance and sexual health. It can increase the release of certain chemicals in the body that narrow blood vessels and raise blood pressure. It has also been linked to side effects such as rapid heartbeat, anxiety and headaches.

For people with hypertension, the risks generally outweigh any potential benefits.

Guarana and Other Caffeine-Containing Supplements

Many energy supplements contain guarana, a plant that naturally contains caffeine. Some products also include concentrated caffeine from other sources.

Caffeine can cause a temporary spike in blood pressure, especially in people who are sensitive to it. While an occasional cup of coffee may not be a problem, highly concentrated caffeine supplements can be much more powerful.

Ephedra and Similar Stimulants

Ephedra has been banned from dietary supplements in the United States because of serious safety concerns, but similar stimulant ingredients may still appear in some products sold online or overseas.

These stimulants can significantly raise blood pressure and increase the risk of heart attack, stroke and other cardiovascular problems.

Talk to a Healthcare Provider Before Taking Supplements

Don't assume that a supplement is safe simply because it's labeled as natural or sold over the counter. Always read ingredient lists carefully and tell your healthcare provider about all vitamins, herbal products and supplements you take to make sure they won't interfere with your medications or affect your blood pressure. A quick conversation can help you avoid unwanted side effects and keep your heart healthier.

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Date Last Reviewed: June 16, 2026

Editorial Review: Andrea Cohen, Editorial Director, Baldwin Publishing, Inc. Contact Editor

Medical Review: Jane Schwartz, RDN, CLT

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